There's a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to decrease afferent pain transmission and generate analgesia. Hence, medication like clonidine that target alpha-2 receptors can influence the transmission of discomfort. This information is not a substitute for health-related https://bookmarkswing.com/story21384419/the-basic-principles-of-onolidine