The conclusion that MMPs mediate the breaking down of type II collagen and that aggrecan is destroyed by relevant metalloproteinases known as adamalysins with thrombospondin motifs (ADAMTSs) is supported by a considerable system of evidence [ten]. Although there isn't any get rid of for osteoarthritis, there are lots of management methods https://www.theorthopaedicandpainpractice.com/all-you-need-to-know-about-osteoarthritis/