Chemotherapy was potentiated by E7449 and single agent had substantial antitumor action in BRCA-deficient xenografts. Furthermore, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, probably by way of TNKS inhibition. Per this likelihood, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and drastically altered expression of Wnt https://lefamulin09876.wssblogs.com/29376121/helping-the-others-realize-the-advantages-of-ml-210